Research

Faculty in the Computational Biology program are engaged in cutting-edge research in a variety of areas, including computational genomics, systems biology, and bioinformatics. The best way to learn about the research being done by our faculty is to visit their websites and read their recent publications. You can find a list of faculty members and their websites on the faculty page. Here are some recent publications by our faculty: You can also browse papers from UVA COBI on PUBMED.

Recent publications

The expected polygenic risk score (ePRS) framework: an equitable metric for quantifying polygenetic risk via modeling of ancestral makeup.

FAIRSCAPE: An Evolving AI-readiness Framework for Biomedical Research.

Refinement of a Published Gene-Physical Activity Interaction Impacting HDL-Cholesterol: Role of Sex and Lipoprotein Subfractions.

Ten simple rules for good model-sharing practices.

Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure.

Demystifying Large Language Models for Medicine: A Primer.

Humans Continue to Outperform Large Language Models in Complex Clinical Decision-Making: A Study with Medical Calculators.

Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood.

General Kernel Machine Methods for Multi-Omics Integration and Genome-Wide Association Testing With Related Individuals.

Clinical and Genomic Features of Androgen Indifferent Prostate Cancer.

Genomic clustering tendency of transcription factors reflects phase-separated transcriptional condensates at super-enhancers.

Endoscopic Ultrasound-Guided Portosystemic Pressure Gradient Correlates with Clinical Parameters and Liver Histology.

Long-COVID incidence proportion in adults and children between 2020 and 2024.

A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.

IGN: Invariable gene set-based normalization for chromatin accessibility profile data analysis.

Considerations for more actionable consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Reply to Mallone R [letter].

The state-of-the-art in cardiac MRI reconstruction: Results of the CMRxRecon challenge in MICCAI 2023.

Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants.

Characterization of a COPD-Associated Nephronectin Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing.

Quantifying Nuclear Structures of Digital Pathology Images Across Cancers Using Transport-Based Morphometry.